Prof Michael Rosen

Bridging length and timescales in cellular organisation.

Research in Michael Rosen’s lab focused on understanding molecular scale mechanisms underlying actin regulatory signaling pathways, primarily using NMR spectroscopy and x-ray crystallography. While they continue to do some work in this area, they have shifted to unravelling the properties of biomolecular condensates, both three-dimensional compartments in the cytoplasm and nucleoplasm, as well as two-dimensional clusters of actin-regulatory signaling molecules at membranes. By connecting concepts in physical chemistry and polymer science with biological molecules, they have helped establish important concepts in this area, for example, they showed that diverse multivalent molecules can undergo assembly and concomitant liquid-liquid phase separation (LLPS) in vitro and in cells, creating structures that closely resemble natural condensates.

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